The Kidney Project’s implantable bioartificial kidney, one that promises to free kidney disease patients from dialysis machines and transplant waiting lists, took another big step toward becoming reality, earning a $650,000 prize from KidneyX for its first-ever demonstration of a functional prototype of its implantable artificial kidney.
KidneyX is a public–private partnership between the U.S. Department of Health and Human Services (HHS) and the American Society of Nephrology (ASN) founded to “accelerate innovation in the prevention, diagnosis, and treatment of kidney diseases.”
The Kidney Project, a nationwide collaboration led by Shuvo Roy, PhD of UC San Francisco and William Fissell, MD of Vanderbilt University Medical Center (VUMC), combined the two essential parts of its artificial kidney, the hemofilter and the bioreactor, and successfully implanted the smartphone-sized device for preclinical evaluation.
For this advance, the team was awarded KidneyX’s Phase 1 Artificial Kidney Prize and was one of six winning teams selected out of an international field.
In the last few years, The Kidney Project successfully tested the hemofilter, which removes waste products and toxins from blood, and the bioreactor, which replicates other kidney functions, like the balance of electrolytes in blood, in separate experiments.
For the Artificial Kidney Prize, the team married the two units into a scaled-down version of the artificial kidney and evaluated its performance in a preclinical model. The units worked in tandem, powered by blood pressure alone, and without the need for blood thinning or immunosuppressant drugs.
Read more at UC San Francisco
Image Credit: UC San Francisco